dna methyltransferase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1904	SGI-1027	DNA Methyltransferase Inhibitor II,SGI1027	Apoptosis , DNA Methyltransferase
	SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.		Apoptosis , DNA Methyltransferase
T15080	DC-05		DNA Methyltransferase , Histone Methyltransferase
	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).		DNA Methyltransferase , Histone Methyltransferase
T7194	CM-272		Apoptosis , DNA Methyltransferase , Histone Methyltransferase
	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T11469	GSK-3484862		DNA Methyltransferase
	GSK-3484862 is a non-covalent Dnmt1 inhibitor. It induces DNA hypomethylation to against cancer.		DNA Methyltransferase
T2495	Lomeguatrib	PaTrin-2	DNA Methyltransferase , DNA Alkylation
	Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .		DNA Methyltransferase , DNA Alkylation
T7718	5-Fluoro-2'-deoxycytidine	FdCyd,2'-DEOXY-5-FLUOROCYTIDINE	DNA Methyltransferase
	5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .		DNA Methyltransferase
T5198	Bobcat339	Bobcat339 hydrochloride	DNA Methyltransferase
	Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.		DNA Methyltransferase
T8967	SW155246		DNA Methyltransferase
	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.		DNA Methyltransferase
T9573	GSK3685032		DNA Methyltransferase
	GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c...		DNA Methyltransferase
T2169	Zebularine	NSC309132,4-Deoxyuridine	DNA Methyltransferase , Autophagy
	Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2...		DNA Methyltransferase , Autophagy
T2038	RG108	N-Phthalyl-L-tryptophan	DNA Methyltransferase
	RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).		DNA Methyltransferase
T7840	2',3',5'-triacetyl-5-Azacytidine	Nsc291930	DNA Methyltransferase , Others
	2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.		DNA Methyltransferase , Others
T3606	γ-Oryzanol	Gamma-Oryzanol,Oliver,Gammariza	DNA Methyltransferase
	γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently b...		DNA Methyltransferase
T3717	Hinokitiol	4-Isopropyltropolone,β-thujaplicin	DNA Methyltransferase , Virus Protease , Estrogen/progestogen Receptor , Nrf2
	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent...
T7457	5-Methyl-2'-deoxycytidine	5-Methyldeoxycytidine,5MedCyd	DNA Methyltransferase , Endogenous Metabolite
	5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.		DNA Methyltransferase , Endogenous Metabolite
T1508	Decitabine	Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA Methyltransferase
	Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis...
T0192	Levetiracetam	UCB L059,SIB-S1	DNA Methyltransferase , Others , Calcium Channel
	Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum...		DNA Methyltransferase , Others , Calcium Channel
T1339	5-Azacytidine	Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-AzaC	Nucleoside Antimetabolite/Analog , DNA Methyltransferase , Antibacterial , Antibiotic , Autophagy
	5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autopha...
T3089	6-Thioguanine	6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine	Apoptosis , DNA Methyltransferase , SARS-CoV , Endogenous Metabolite , DUB , Autophagy
	6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T16269	Nanaomycin A		DNA Methyltransferase , Dehydrogenase , Parasite
	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).		DNA Methyltransferase , Dehydrogenase , Parasite